Lauren B Andrews

This study demonstrates the transferability of homoserine lactone sensors between Bacillales bacteria, enabling programmable interphyla communication between Gram-negative and Gram-positive species.

The paper evaluates CRISPRi system performance across different E. coli strains and develops a dual gRNA system for improved repression in clinical isolates.

The paper identifies highly specific LasR variants for HSL signals through mutagenesis and screening, improving signal discrimination in microbial consortia.

The paper develops synthetic HSL sensors in Bacillus subtilis using LuxR-type regulators and combinatorial promoters, achieving up to 293-fold activation and identifying sequence-function relationships.

This paper designs genetic circuits in Escherichia coli to feedback control GABA production, improving biosynthesis through engineered NOT gates and biosensors.