Next-generation cytosine base editors with minimized unguided DNA and RNA off-target events and high on-target activity
Yi Yu, Thomas Leete, David A. Born, Lauren Young, Luis Alberto Barrera, Seung‐Joo Lee, Holly A. Rees, Giuseppe Ciaramella, Nicole M. Gaudelli
The paper develops next-generation cytosine base editors with reduced off-target DNA and RNA deamination and improved on-target activity.
Nature Communications · Apr 28, 2020Peer-reviewedGenomics