Author

Holly A. Rees

Beam Therapeutics (United States)ORCID 0000-0002-6336-8596Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genomics· 2 Bioinformatics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 2 Assay:CRISPR screen· 1 Assay:DNA methylation· 1 Research Focus:drug response / drug discovery· 1 Research Focus:perturbation response prediction· 1 Research Focus:variant calling· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

David A. BorniD· 2 shared Giuseppe CiaramellaiD· 2 shared Jason M. Gehrke· 2 shared Luis Alberto BarreraiD· 2 shared Nicole M. GaudelliiD· 2 shared Seung‐Joo LeeiD· 2 shared Aaron Edwards· 1 shared Alexander Liquori· 1 shared

Activity by Year

2019-2020 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersGenomics

David A. BornORCID

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Author profile →

3 papers

Recent·Most cited

Next-generation cytosine base editors with minimized unguided DNA and RNA off-target events and high on-target activity

Yi Yu, Thomas Leete, David A. Born, Lauren Young, Luis Alberto Barrera, Seung‐Joo Lee, Holly A. Rees, Giuseppe Ciaramella, Nicole M. Gaudelli

The paper develops next-generation cytosine base editors with reduced off-target DNA and RNA deamination and improved on-target activity.

Nature Communications · Apr 28, 2020Peer-reviewedGenomics

Directed Evolution of Adenine Base Editors with Increased Activity and Therapeutic Application

Nicole M. Gaudelli, Dieter K. Lam, Holly A. Rees, Noris M. Solá-Esteves, Luis Alberto Barrera, David A. Born, Aaron Edwards, Jason M. Gehrke, Seung‐Joo Lee, Alexander Liquori, Ryan C. Murray, Michael S. Packer, Conrad Rinaldi, Ian M. Slaymaker, Jonathan S. Yen, , Giuseppe Ciaramella

This paper evolves adenine base editors (ABE8s) to improve editing efficiency and demonstrates their therapeutic application in human cells.

Nature Biotechnology · Apr 13, 2020Peer-reviewedGenomics

Analysis and comparison of genome editing using CRISPResso2

Kendell Clement, Holly A. Rees, Matthew C. Canver, Jason M. Gehrke, Rick Farouni, Jonathan Y. Hsu, Mitchel A. Cole, David R. Liu, J. Keith Joung, Daniel E. Bauer, Luca Pinello

CRISPResso2 is a software tool for analyzing genome editing data, providing allele-specific quantification and scalable alignment to assess editing efficiency and safety.

Nature Biotechnology · Feb 26, 2019Peer-reviewedBioinformatics