Author

Luis Alberto Barrera

Beam Therapeutics (United States)ORCID 0000-0003-0612-6416Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genomics· 2 Genetics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Assay:CRISPR screen· 1 Assay:DNA methylation· 1 Research Focus:drug response / drug discovery· 1 Organism:mouse· 1 Research Focus:perturbation response prediction· 1

Frequent Co-Authors

David A. BorniD· 2 shared Giuseppe CiaramellaiD· 2 shared Holly A. ReesiD· 2 shared Nicole M. GaudelliiD· 2 shared Seung‐Joo LeeiD· 2 shared Aaron Edwards· 1 shared Alexander Liquori· 1 shared Anne Bothmer· 1 shared

Activity by Year

2017-2020 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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2 shared papersGenomics

David A. BornORCID

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3 papers

Recent·Most cited

GenomicsNature CommunicationsPeer-reviewedApr 28, 2020

Next-generation cytosine base editors with minimized unguided DNA and RNA off-target events and high on-target activity

Yi Yu, Thomas Leete, David A. Born…·Nicole M. Gaudelli

The paper develops next-generation cytosine base editors with reduced off-target DNA and RNA deamination and improved on-target activity.

194 citationstop 1%

humanDNA methylation

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GenomicsNature BiotechnologyPeer-reviewedApr 13, 2020

Directed Evolution of Adenine Base Editors with Increased Activity and Therapeutic Application

Nicole M. Gaudelli, Dieter K. Lam, Holly A. Rees…·Giuseppe Ciaramella

This paper evolves adenine base editors (ABE8s) to improve editing efficiency and demonstrates their therapeutic application in human cells.

530 citationstop 1%

humanCRISPR screen

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GeneticsbioRxivPreprintJul 10, 2017

The experimental design and data interpretation in “Unexpected mutations after CRISPR–Cas9 editing in vivo” by Schaefer et al. are insufficient to support the conclusions drawn by the authors

Christopher J. Wilson, Tim J. Fennell, Anne Bothmer…·Vic E. Myer

The paper critiques the experimental design and data interpretation in a previous study claiming CRISPR-Cas9 causes unexpected mutations, arguing the conclusions are not supported by the evidence.

12 citations

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