Engineered heat-stable variants of Trypanosoma cruzi flagellar protein Tc24 enable serological detection of Chagas disease
Sagar Batra, Christopher Waugh, Gemma Harris, Frederick W. Muskett, Tiberiu‐Marius Gianga, Rohanah Hussain, Giuliano Siligardi, Laurence Turpin, Mallory Draye, Pascal Mertens, Barrie C. Rooney, Michael A. Miles, Tapan Bhattacharyya, Ivan Campeotto
The paper engineers heat-stable variants of Tc24, a Trypanosoma cruzi antigen, enabling serological detection of Chagas disease without refrigeration.
bioRxiv · Aug 23, 2025 · PreprintBiochemistry