The paper shows TRIM21 becomes an autoantigen by forming pro-inflammatory immune complexes after lytic cell death, which are taken up by macrophages and drive inflammation.

Science Immunology · Apr 17, 2026Peer-reviewedImmunology

Engineered heat-stable variants of Trypanosoma cruzi flagellar protein Tc24 enable serological detection of Chagas disease

Sagar Batra, Christopher Waugh, Gemma Harris, Frederick W. Muskett, Tiberiu‐Marius Gianga, Rohanah Hussain, Giuliano Siligardi, Laurence Turpin, Mallory Draye, Pascal Mertens, Barrie C. Rooney, Michael A. Miles, Tapan Bhattacharyya, Ivan Campeotto

The paper engineers heat-stable variants of Tc24, a Trypanosoma cruzi antigen, enabling serological detection of Chagas disease without refrigeration.

bioRxiv · Aug 23, 2025 · PreprintBiochemistry

Defining the mechanism of galectin-3-mediated TGF-β1 activation and its role in lung fibrosis.

J Calver, Nimesh R. Parmar, Gemma Harris, Ryan M. Lithgo, Panayiota Stylianou, Fredrik R. Zetterberg, Bibek Gooptu, Alison C. MacKinnon, Stephen B. Carr, Lee Anthony Borthwick, David J. Scott, Iain D. Stewart, Robert J. Slack, Gisli R. Jenkins, Alison E. John

This paper investigates how galectin-3 enhances TGF-β1 activation and signaling in lung fibroblasts, contributing to idiopathic pulmonary fibrosis.

Journal of Biological Chemistry · Apr 17, 2024Peer-reviewedMolecular Biology

Purine-rich RNA sequences in the 5'UTR site-specifically regulate eIF4A1-unwinding through eIF4A1-multimerisation to facilitate translation

Tobias Schmidt, Adrianna Dąbrowska, Joseph A. Waldron, Kelly Hodge, Grigorios Koulouras, Mads Gabrielsen, June Munro, David C. Tack, Gemma Harris, Ewan James McGhee, David J. Scott, Leo M. Carlin, Danny T. C. Huang, John P. C. Le Quesne, Sara R. Zanivan, , Martin Bushell

The paper identifies AG-rich RNA sequences in 5'UTRs that regulate eIF4A1 multimerisation to enhance translation of oncogenic mRNAs.

bioRxiv · Aug 8, 2022 · PreprintMolecular Biology