Tiberiu‐Marius Gianga

The paper reports the structural analysis of a minimal kinase domain of HRI, showing its ligand-binding conformation and non-productive state, supporting drug discovery for blood cancer.

The paper shows that intrinsically disordered regions in proteins amplify DNA structural fluctuations, enabling allostery in transcription factor binding.

The paper engineers heat-stable variants of Tc24, a Trypanosoma cruzi antigen, enabling serological detection of Chagas disease without refrigeration.