Giuliano Siligardi

Structure-function studies of HRIKD-{triangleup}KI, a Minimal Kinase Domain of Human Heme-Regulated Inhibitor Kinase

The paper reports the structural analysis of a minimal kinase domain of HRI, showing its ligand-binding conformation and non-productive state, supporting drug discovery for blood cancer.

Protein disorder controls allostery in DNA

The paper shows that intrinsically disordered regions in proteins amplify DNA structural fluctuations, enabling allostery in transcription factor binding.

Engineered heat-stable variants of Trypanosoma cruzi flagellar protein Tc24 enable serological detection of Chagas disease

The paper engineers heat-stable variants of Tc24, a Trypanosoma cruzi antigen, enabling serological detection of Chagas disease without refrigeration.

A conformational switch controlling the toxicity of the prion protein

This study identifies an H-latch conformational switch in PrPC that drives prion toxicity and shows that disrupting this switch can protect against prion-related neurodegeneration.