Negative selection in humans and fruit flies involves synergistic epistasis
Mashaal Sohail, Olga A Vakhrusheva, Jae Hoon Sul, Sara Pulit, Laurent Francioli, GoNL Consortium, Alzheimers Disease Neuroimaging Initiative, Leonard H van den Berg, Jan H Veldink, Paul de Bakker, Georgii A Bazykin, Alexey S Kondrashov, Shamil Sunyaev
The paper detects underdispersion of rare loss-of-function alleles in humans and fruit flies, suggesting synergistic epistasis in negative selection.
Science · May 5, 2017Peer-reviewedEvolutionary Biology