Author

Paul de Bakker

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Evolutionary Biology· 1 Genetics· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Approach:statistical model· 2 Assay:whole-genome sequencing· 2 Research Focus:chromatin & epigenetic regulation· 1 Assay:DNA methylation· 1 Organism:Drosophila· 1 Research Focus:genome assembly· 1 Research Focus:imputation· 1

Frequent Co-Authors

Abdel Abdellaoui· 1 shared Alexander Schöenhuth· 1 shared Alexey S Kondrashov· 1 shared Alzheimers Disease Neuroimaging Initiative· 1 shared André G. Uitterlinden· 1 shared Bradley P. Coe· 1 shared Cisca Wijmenga· 1 shared Djie Tjwan Thung· 1 shared

Activity by Year

2016-2017 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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1 shared paperGenetics

Abdel Abdellaoui

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2 papers

Recent·Most cited

Negative selection in humans and fruit flies involves synergistic epistasis

Mashaal Sohail, Olga A Vakhrusheva, Jae Hoon Sul, Sara Pulit, Laurent Francioli, GoNL Consortium, Alzheimers Disease Neuroimaging Initiative, Leonard H van den Berg, Jan H Veldink, Paul de Bakker, Georgii A Bazykin, Alexey S Kondrashov, Shamil Sunyaev

The paper detects underdispersion of rare loss-of-function alleles in humans and fruit flies, suggesting synergistic epistasis in negative selection.

Science · May 5, 2017Peer-reviewedEvolutionary Biology

A high-quality reference panel reveals the complexity and distribution of structural genome changes in a human population

Jayne Y. Hehir-Kwa, Tobias Marschall, Wigard P. Kloosterman, Laurent C. Francioli, Jasmijn A. Baaijens, Louis J. Dijkstra, Abdel Abdellaoui, Vyacheslav Koval, Djie Tjwan Thung, René Wardenaar, Ivo Renkens, Bradley P. Coe, Patrick Deelen, Joep de Ligt, Eric-Wubbo Lameijer, , Victor Guryev

This study creates a high-quality reference panel of structural variants from 769 Dutch individuals, revealing new variants and their linkage to known SNPs, improving imputation accuracy for genome-wide association studies.

bioRxiv · Jul 2, 2016 · PreprintGenetics