TDP-43 stabilizes transcripts encoding stress granule protein G3BP1: potential relevance to ALS/FTD
Hadjara Sidibé, Yousra Khalfallah, Shangxi Xiao, Nicolás Gómez, Elizabeth M.H. Tank, Geneviève Di Tomasso, Eric Bareke, Anaïs Aulas, Paul M. McKeever, Ze’ev Melamed, Laurie Destroimaisons, Jade-Emmanuelle Deshaies, Lorne H. Zinman, J. Alex Parker, Pascale Legault, , Christine Vande Velde
This study shows TDP-43 stabilizes G3BP1 transcripts via direct binding, and TDP-43 depletion reduces G3BP1 protein levels, contributing to stress granule dysfunction in ALS/FTD.
bioRxiv · Sep 15, 2020 · PreprintNeuroscience