Christine Vande Velde

This study identifies ZDHHC17 as a key enzyme linking S-acylation to neurodegenerative diseases by modulating protein localization and toxicity.

This study shows TDP-43 pathology occurs independently of stress granules in motor neurons, challenging existing models of TDP-43 pathogenesis.

The paper shows that TDP-43 pathology causes a cryptic exon in G3BP1 to be included in neurons, leading to a protein that disrupts stress granule dynamics in ALS/FTD.

This study shows TDP-43 stabilizes G3BP1 transcripts via direct binding, and TDP-43 depletion reduces G3BP1 protein levels, contributing to stress granule dysfunction in ALS/FTD.

The paper identifies TRAF6 as an interactor of misfolded SOD1 in ALS, showing it promotes aggregation through ubiquitination.