Author

Shangxi Xiao

University of Toronto

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 2

Signature Assays, Organisms & Methods

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Organism:human· 2 Research Focus:cell type annotation· 1 Research Focus:database / resource· 1 Approach:deep learning· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Assay:scRNA-seq· 1

Frequent Co-Authors

Janice RobertsoniD· 2 shared Lorne H. ZinmaniD· 2 shared Paul M. McKeeveriD· 2 shared Aiden M. Sababi· 1 shared Anaïs AulasiD· 1 shared Christine SatoiD· 1 shared Christine Vande VeldeiD· 1 shared Danielle MorenoiD· 1 shared

Activity by Year

2020-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersNeuroscience

Janice RobertsonORCID

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2 papers

Recent·Most cited

Single-nucleus transcriptome atlas of orbitofrontal cortex in amyotrophic lateral sclerosis with a deep learning-based decoding of alternative polyadenylation mechanisms

Paul M. McKeever, Aiden M. Sababi, Raghav Sharma, Zhiyu Xu, Shangxi Xiao, Philip McGoldrick, Troy Ketela, Christine Sato, Danielle Moreno, Naomi P. Visanji, Gábor Géza Kovács, Julia Lee Keith, Lorne H. Zinman, Ekaterina A. Rogaeva, Hani Goodarzi, , Janice Robertson

The paper constructs a single-nucleus transcriptome atlas of the orbitofrontal cortex in ALS and identifies cell-type-specific transcriptional changes, introducing a deep learning model to analyze alternative polyadenylation.

Cell Genomics · Sep 17, 2025Peer-reviewedNeuroscience

TDP-43 stabilizes transcripts encoding stress granule protein G3BP1: potential relevance to ALS/FTD

Hadjara Sidibé, Yousra Khalfallah, Shangxi Xiao, Nicolás Gómez, Elizabeth M.H. Tank, Geneviève Di Tomasso, Eric Bareke, Anaïs Aulas, Paul M. McKeever, Ze’ev Melamed, Laurie Destroimaisons, Jade-Emmanuelle Deshaies, Lorne H. Zinman, J. Alex Parker, Pascale Legault, , Christine Vande Velde

This study shows TDP-43 stabilizes G3BP1 transcripts via direct binding, and TDP-43 depletion reduces G3BP1 protein levels, contributing to stress granule dysfunction in ALS/FTD.

bioRxiv · Sep 15, 2020 · PreprintNeuroscience