Structural basis for the context-specific action of classic peptidyl transferase inhibitors.
Egor A. Syroegin, Laurin Flemmich, Dorota Klepacki, Nora Vázquez‐Laslop, Ronald Micura, Yury S. Polikanov
The paper presents high-resolution structures of ribosomal complexes with chloramphenicol and specific nascent peptides, revealing how amino acids in the nascent chain modulate drug affinity and explain context-specific inhibition of translation.
Nature Structural & Molecular Biology · Feb 1, 2022Peer-reviewedMolecular Biology