Egor A. Syroegin

This study presents structural analysis of ribosome-nascent chain complexes to elucidate how macrolides inhibit bacterial translation in a context-specific manner.

The paper shows FaRel2, a toxSAS, specifically targets tRNAGly and tRNAThr by recognizing the acceptor stem, with structural differences explaining specificity variations among toxSASs.

The paper introduces CIMPLE, a rationally designed CRISPRi pooled library, to uncover antibiotic targets by improving genomic coverage of essential genes during drug exposure.

This study determines the structural basis of Cfr-mediated antimicrobial resistance and identifies mechanisms for evading it through ribosome structures with Cfr-modified 23S rRNA.

The paper reports structures of non-arrested ribosome nascent chain complexes, revealing new insights into ribosome function and the mechanism of the peptidyl transferase center.

The paper presents high-resolution structures of ribosomal complexes with chloramphenicol and specific nascent peptides, revealing how amino acids in the nascent chain modulate drug affinity and explain context-specific inhibition of translation.