Oxidative-stress related increase in keratoconus tear MDA and GPX3 while NRF2-antioxidant functions decrease in stromal cells
Madhuri Amulya Koduri, Mackenzie E. Charter, Rohini Sonar, Rashmi Deshmukh, Christina Rapp Prescott, Rose Mandel, Lawrence Sperber, Ting‐Fang Lee, Elias H. Kahan, Ilyse D. Haberman, Vivek Singh, Andrea L. Blitzer, George Maiti, Shukti Chakravarti
This study identifies increased MDA and GPX3 in KC tears and NRF2 dysfunction in stromal cells, suggesting potential biomarkers and therapeutic targets for keratoconus.
bioRxiv · Nov 13, 2025 · PreprintCell Biology