George Maiti

Extracellular matrix proteoglycans lumican and biglycan promote innate immune signals and viral clearance in HSV-1 infections of mouse corneas

This study shows that ECM proteoglycans lumican and biglycan enhance antiviral immunity in HSV-1 corneal infections by promoting immune cell recruitment and cytokine production.

Oxidative-stress related increase in keratoconus tear MDA and GPX3 while NRF2-antioxidant functions decrease in stromal cells

This study identifies increased MDA and GPX3 in KC tears and NRF2 dysfunction in stromal cells, suggesting potential biomarkers and therapeutic targets for keratoconus.

Paracrine regulations of IFN-γ secreting CD4+ T cells by lumican and biglycan are protective in allergic contact dermatitis

This study shows that lumican and biglycan, ECM proteoglycans, protect against allergic contact dermatitis by limiting proinflammatory CD4+ T cells through paracrine regulation.

Single cell RNA-seq identifies developing corneal cell fates in the human cornea organoid

This study uses single-cell RNA-seq to map cell fates in human cornea organoids and identifies developmental states of corneal cell types.