Extracellular matrix proteoglycans lumican and biglycan promote innate immune signals and viral clearance in HSV-1 infections of mouse corneas
George Maiti, Madhuri Amulya Koduri, Elizabeth Shin, Yoonchul Shin, Trisha Sinha, Alireza Khodadadi‐Jamayran, Hongmin Yun, Anthony J. St. Leger, Shukti Chakravarti
This study shows that ECM proteoglycans lumican and biglycan enhance antiviral immunity in HSV-1 corneal infections by promoting immune cell recruitment and cytokine production.
bioRxiv · Sep 18, 2026 · PreprintImmunology