Metabolic Crossroads: AMDHD2 Couples the Hexosamine Biosynthetic Pathway to Acetyl-CoA Homeostasis in Pluripotent Stem Cells
Virginia Kroef, Lea Hund, Yasmin Barenco Abbas, Norito Tamura, Jenny Fröhlich, Ann‐Kathrin Huber, Syed Musa Ali, Lena Wischhof, Hannah Scheiblich, Patrick Giavalisco, Martin Sebastian Denzel, Peter Tessarz, Ina Huppertz
This study identifies AMDHD2 as a key regulator linking the hexosamine biosynthetic pathway to acetyl-CoA homeostasis in mouse embryonic stem cells, revealing a metabolic mechanism critical for differentiation.
bioRxiv · Aug 20, 2025 · PreprintMolecular Biology