Martin Sebastian Denzel

This study identifies AMDHD2 as a key regulator linking the hexosamine biosynthetic pathway to acetyl-CoA homeostasis in mouse embryonic stem cells, revealing a metabolic mechanism critical for differentiation.

The paper shows ATF4 rewires mitochondrial one-carbon metabolism during infection to restrict Toxoplasma growth via folate competition.

The paper introduces SKI TRIP, a method for profiling cell type-specific translation in C. elegans using single-copy knock-in of a FLAG-tagged ribosomal subunit.

The paper identifies that NHR-8 regulates P-glycoproteins in C. elegans, uncoupling xenobiotic stress resistance from longevity in osm-3 mutants.

This study identifies eIF2B's role in extending lifespan by inhibiting the integrated stress response in C. elegans, improving protein homeostasis without altering overall protein synthesis.

This study shows that miR-1 regulates lysosomal v-ATPase and biogenesis in C. elegans muscle to affect contractility during proteotoxic stress and ageing.