Patrick Giavalisco

Metabolic Crossroads: AMDHD2 Couples the Hexosamine Biosynthetic Pathway to Acetyl-CoA Homeostasis in Pluripotent Stem Cells

This study identifies AMDHD2 as a key regulator linking the hexosamine biosynthetic pathway to acetyl-CoA homeostasis in mouse embryonic stem cells, revealing a metabolic mechanism critical for differentiation.

Multi-Omics Analysis of Heat Stress-Induced Memory in Arabidopsis

This study uses multi-omics analysis to investigate heat stress memory in Arabidopsis, identifying temporal transcriptomic, proteomic, and metabolomic responses during recovery.

Metabolic immunity to infection is driven by mitochondrial one-carbon metabolism

The paper shows ATF4 rewires mitochondrial one-carbon metabolism during infection to restrict Toxoplasma growth via folate competition.

Autophagy regulator ATG5 preserves cerebellar function by safeguarding its glycolytic activity

This study shows that autophagy regulator ATG5 protects cerebellar Purkinje cells by maintaining glycolytic activity, preventing neurodegeneration through regulation of glucose transporter 2.

Sodium butyrate is incorporated into central metabolism in fly head while inducing oxygen consumption increase

This study shows that butyrate is metabolized into the TCA cycle in fly heads and increases oxygen consumption without affecting proteome or acetylome.

Liver-like glycogen metabolism supports glycolysis in naked mole-rat heart during ischaemia

This study identifies a unique glycogen metabolism in naked mole-rat hearts during ischaemia, involving liver-like mechanisms and amylase activation for enhanced glycolytic flux and ATP maintenance.

Mediobasal hypothalamic FKBP51 acts as a molecular switch linking autophagy to whole-body metabolism

This study identifies FKBP51 as a molecular switch linking autophagy to metabolism in the mediobasal hypothalamus, showing its role in obesity regulation.

Metabolic control of adult neural stem cell self-renewal by the mitochondrial protease YME1L

This study identifies YME1L as a mitochondrial protease that regulates metabolic state transitions in adult neural stem cells, ensuring self-renewal and preventing premature differentiation.

Chloroplast competition is controlled by lipid biosynthesis in evening primroses

This study identifies rapidly evolving chloroplast genes that control lipid biosynthesis and influence plastid competitiveness in evening primroses, leading to uniparental or biparental inheritance.