HrasG12V induces follicular thyroid cancer with attenuated MAPK activation and increased latency compared to KrasG12D
Nicholas E. Bambach, Katherine Labella, Lee Ann Jolly, Diana Isabel Cruz, Nicole A. Massoll, Antonio Di Cristofano, Aime T. Franco
This study compares the effects of HrasG12V and KrasG12D mutations in thyroid cancer, showing HrasG12V induces follicular thyroid cancer with delayed MAPK activation and longer latency.
bioRxiv · Sep 15, 2026 · PreprintCancer Biology