Aime T. Franco

This study compares the effects of HrasG12V and KrasG12D mutations in thyroid cancer, showing HrasG12V induces follicular thyroid cancer with delayed MAPK activation and longer latency.

This study identifies KEAP1 mutations in thyroid cancer, showing they activate the NRF2 pathway, promote cell growth and migration, and reduce drug response.

The paper uses single-nuclei RNA sequencing to analyze pediatric thyroid cells, identifying seven major cell types and seven thyrocyte subclusters with distinct functions.

SWANS is a configurable scRNA-seq analysis pipeline that integrates multiple methods and generates interactive reports for data visualization and comparison.

The paper examines platelet parameters in 22q11.2 deletion syndrome patients, finding that deletion status of GP1BB, not surface expression, determines platelet counts and that counts decrease with age.

This study shows that genetic subtypes of pediatric thyroid cancer, particularly RET/NTRK fusions, are linked to worse clinical outcomes compared to RAS- or BRAF-mutant subtypes.

The paper develops ELIGOS, a bioinformatic tool to detect RNA modifications and secondary structures using native RNA sequencing data from E. coli, yeast, and human cells.