Establishment of a Systemic Lupus Erythematosus Mouse Model in Humanized CD3/CD19 Mice and Evaluation of the Efficacy of a Human Bispecific Antibody
Yaqi Du, Lijun Zhou, Jiaxuan Shao, Yanling Wang, Menghan Cui, Shuang Li, Yu‐Chieh Su, Lei Ci, Ruilin Sun
This paper establishes a humanized CD3/CD19 mouse model of SLE and evaluates the efficacy of a human bispecific antibody in treating the disease.
bioRxiv · Aug 21, 2025 · PreprintImmunology