A selective Cullin 3 RING E3 ligase inhibitor attenuates hyperglycemia via dual insulin sensitizing and insulinotropic action
LIJIE GU, LEI XIONG, Mohammad Hasan, Yanhong Du, Timothy Wu, Tiangang Li
This study identifies DI-1859, a selective Cul3 neddylation inhibitor, that reduces hyperglycemia by enhancing insulin sensitivity and secretion in mice.
Diabetes · Jul 31, 2026Peer-reviewedPhysiology