Author

Lei Xiong

MIT Computer Science and Artificial Intelligence LaboratoryORCID 0000-0002-4614-4777Unclaimed ORCID profile · follow to get notified of new preprints

Additional preprints under this name without ORCID

LEI XIONG1 paper · University of Oklahoma

Biology Disciplines

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Cancer Biology· 1 Genomics· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Assay:Ribo-seq· 1 Approach:statistical model· 1 Approach:transformer / foundation model· 1 Research Focus:variant effect prediction· 1

Frequent Co-Authors

Anshul Bharat KundajeiD· 1 shared Carles A. BoixiD· 1 shared Catherine R. ZhangiD· 1 shared Chengyu LiiD· 1 shared Christine Y. YehiD· 1 shared Jialin HeiD· 1 shared Jingyun LiiD· 1 shared Jiuhong NaniD· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperCancer Biology

Anshul Bharat KundajeORCID

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2 papers

Recent·Most cited

Cancer BiologybioRxivPreprintAug 18, 2025

Cancer cell phagocytosis induces an anti-inflammatory gene regulatory program in macrophages

Catherine R. Zhang, Lei Xiong, Mingxin Gu…·Michael Cory Bassik

This study shows that cancer cell phagocytosis by macrophages induces an anti-inflammatory gene regulatory program, promoting immunosuppression and tumor growth.

3 citations

humanbulk RNA-seq

𝕏 PostBluesky

GenomicsbioRxivPreprintFeb 26, 2024

Deep learning modeling of ribosome profiling reveals regulatory underpinnings of translatome and interprets disease variants

Jialin He, Lei Xiong, Shaohui Shi…·Xushen Xiong

The paper introduces Translatomer, a transformer model that predicts cell-type-specific translation from mRNA and sequence data, identifies disease variants affecting translation, and reveals non-eQTL regulatory mechanisms.

DOI 10.1101/2024.02.26.582217

𝕏 PostBluesky