Tiangang Li

This study identifies DI-1859, a selective Cul3 neddylation inhibitor, that reduces hyperglycemia by enhancing insulin sensitivity and secretion in mice.

This study shows that MLKL in hepatocytes promotes liver aging by inducing senescence and mitochondrial dysfunction without causing necroptosis.

This study investigates how CDO1-mediated cysteine catabolism in hepatocytes and adipocytes affects diet-induced obesity and fatty liver in mice, finding differential impacts based on tissue-specific manipulation.

The paper shows aerobic capacity and exercise enhance bile acid metabolism, which is critical for reducing hepatic steatosis in mice.