Leilani R. Astrab

An agent-based model suggests how senescent cell behavior and matrix mechanics drive pulmonary fibrosis in aged mice

The paper develops an agent-based model to show how senescent cell behavior and tissue mechanics contribute to pulmonary fibrosis in aged mice.

Lung tissue viscoelasticity is preserved with bleomycin-induced fibrosis in mice

The paper examines lung viscoelasticity in bleomycin-induced fibrosis in mice, finding preserved viscoelastic properties despite increased stiffness.

Cadherin-11 integrates Piezo1 and interleukin-6 signaling to promote fibroblast activation

This study identifies CDH11 as a mediator of fibroblast activation by integrating mechanical and inflammatory signals in pulmonary fibrosis.

Direct M2 macrophage co-culture overrides viscoelastic hydrogel mechanics to promote fibroblast activation

This study shows that direct M2 macrophage co-culture promotes fibroblast activation regardless of hydrogel stiffness, mediated by IL6 signaling.