Cell-to-cell variability in JAK2/STAT5 pathway components and cytoplasmic volumes define survival threshold in erythroid progenitor cells
Lorenz Adlung, Paul L. Stapor, Christian Tönsing, Leonard Schmiester, Luisa E. Schwarzmüller, Lena Postawa, Dantong Wang, Jens Timmer, Ursula Klingmüller, Jan Hasenauer, Marcel Schilling
The paper models single-cell variability in JAK2/STAT5 signaling and cytoplasmic volume to explain how erythroid progenitor cells transition from binary survival/apoptosis decisions to graded population responses upon Epo stimulation.
Cell Reports · Aug 1, 2021Peer-reviewedSystems Biology