Marcel Schilling

Integration of proteomic data from cell lines and tumors

This paper introduces ProtInt, a deep learning framework for integrating proteomic data from cancer cell lines and tumors, showing improved performance over existing methods.

msBayesImpute: A Versatile Framework for Addressing Missing Values in Biomedical Mass Spectrometry Proteomics Data

msBayesImpute improves missing value handling in proteomics data by integrating Bayesian factorization and probabilistic dropout models, outperforming existing methods in imputation and normalization.

Loss of the Y chromosome drives epigenetic and transcriptomic plasticity in lung adenocarcinoma

This study shows that loss of the Y chromosome in lung adenocarcinoma causes epigenetic and transcriptomic changes that increase lineage plasticity and poor clinical outcomes.

Lysis buffer selection guidance for mass spectrometry-based global proteomics including studies on the intersection of signal transduction and metabolism

This study compares four lysis buffers for proteomics, finding SDS most reliable and advocating a dual-sample approach to maximize proteome coverage.

Basal MET Phosphorylation is an Indicator of Hepatocyte Dysregulation in Liver Disease

The paper identifies elevated basal MET phosphorylation as a marker of hepatocyte dysregulation in liver disease, correlating with patient outcomes after surgery.

Cell-to-cell variability in JAK2/STAT5 pathway components and cytoplasmic volumes define survival threshold in erythroid progenitor cells

The paper models single-cell variability in JAK2/STAT5 signaling and cytoplasmic volume to explain how erythroid progenitor cells transition from binary survival/apoptosis decisions to graded population responses upon Epo stimulation.

Identification of Interleukin1β as an Amplifier of Interferon alpha-induced Antiviral Responses

This study identifies IL1β as an amplifier of IFN-induced antiviral responses through mathematical modeling and experimental validation.