Luisa E. Schwarzmüller

Multi-omics, organoid-based modeling reveals an SRC/mTOR-dependent fetal-like stem cell trajectory in colorectal cancer

The paper identifies a fetal-like stem cell trajectory in colorectal cancer using multi-omics and organoid models, linked to poor prognosis and SRC/mTOR dependency.

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and Tamoxifen in a luminal A breast cancer model

This study shows PAK1 activation leads to different resistance mechanisms against Tamoxifen and aromatase inhibitors in luminal A breast cancer by affecting apoptosis and proliferation through distinct pathways.

GLYATL1 is associated with metabolic and epigenetic changes and with endocrine resistance in luminal breast cancer

This study identifies GLYATL1 as a mediator of endocrine resistance in luminal breast cancer by promoting metabolic and epigenetic changes that counteract estrogen deprivation.

Inducible re-epithelialization of cancer cells increases autophagy and DNA damage: implications for breast cancer dormancy

The paper shows that inducing epithelial traits in breast cancer cells increases autophagy and DNA damage, potentially contributing to tumor dormancy and reactivation.

Lysis buffer selection guidance for mass spectrometry-based global proteomics including studies on the intersection of signal transduction and metabolism

This study compares four lysis buffers for proteomics, finding SDS most reliable and advocating a dual-sample approach to maximize proteome coverage.

Cell-to-cell variability in JAK2/STAT5 pathway components and cytoplasmic volumes define survival threshold in erythroid progenitor cells

The paper models single-cell variability in JAK2/STAT5 signaling and cytoplasmic volume to explain how erythroid progenitor cells transition from binary survival/apoptosis decisions to graded population responses upon Epo stimulation.