TBCK-deficiency leads to compartment-specific mRNA and lysosomal trafficking defects in patient-derived neurons
Marco Flores‐Méndez, Jesus A Tintos-Hernández, Leonardo Ramos-Rodriguez, Leann Miles, Tsz Y. Lo, Yuanquan Song, Xilma Rosa Ortiz-Gonzalez
This study identifies TBCK's role in mRNA and lysosomal trafficking in neurons, showing that TBCK deficiency causes compartment-specific trafficking defects contributing to neurodegeneration.
bioRxiv · Mar 2, 2025 · PreprintNeuroscience