Ketogenesis is dispensable for the metabolic adaptations to caloric restriction
Chung‐Yang Yeh, Lexie Borgelt, Brynn J. Vogt, Alyssa A. Clark, Ted T. Wong, Isaac Grunow, Michelle M. Sonsalla, Reji Babygirija, Yang Liu, Michaela E. Trautman, Mariah F. Calubag, Bailey A. Knopf, Fan Xiao, Dudley W. Lamming
This study shows that ketogenesis is not essential for the metabolic benefits of caloric restriction in mice, as Hmgcs2 deletion does not impair key metabolic adaptations.
Aging Cell · Dec 10, 2025Peer-reviewedPhysiology