Michaela E. Trautman

Restriction of individual branched-chain amino acids has distinct effects on the development and progression of Alzheimers disease in 3xTg mice

This study examines the effects of restricting individual branched-chain amino acids on Alzheimer's disease progression in 3xTg mice, finding sex-specific cognitive and metabolic benefits.

Ketogenesis is dispensable for the metabolic adaptations to caloric restriction

This study shows that ketogenesis is not essential for the metabolic benefits of caloric restriction in mice, as Hmgcs2 deletion does not impair key metabolic adaptations.

Dietary isoleucine content defines the metabolic and molecular response to a Western diet

This study shows that reducing dietary isoleucine improves metabolic health in mice on a Western diet, with distinct molecular responses across sexes and strains.

Dietary lipid is largely deposited in skin and rapidly affects insulating properties

The paper shows dietary lipid is deposited in skin, altering its thermal properties and energy regulation within days.

Rapamycin does not compromise physical performance or muscle hypertrophy after PoWeR while intermittent rapamycin alleviates glucose disruptions by frequent rapamycin

This study investigates how different rapamycin dosing schedules affect physical performance and metabolic outcomes in mice undergoing voluntary exercise training.

Acarbose ameliorates Western diet-induced metabolic and cognitive impairments in the 3xTg mouse model of Alzheimer's disease

This study shows acarbose improves metabolic health and reduces cognitive deficits in Western diet-fed 3xTg mice, suggesting it may help prevent or delay Alzheimer's disease.