Age Dependent Immunopathology Drives Pneumonia-Associated Cardiac Dysfunction During Streptococcus pneumoniae Infection
Sameer Salam Matoo, Naresh Kumar, Mariam A. Salem, Alison Thomas, Aakash Shah, Pankaj Kumar, Miqdad O. Dhariwala, Liao Zhiwei, Haitao Wen, Stephanie Sevaue, Latha Prabha Ganesan, William P. Lafuse, Rachael Philips, Patrick L. Collins, Murugesan V. S. Rajaram
This study shows aging worsens cardiac dysfunction during Streptococcus pneumoniae infection through inflammation and impaired immune responses, with potential therapeutic targets identified.
bioRxiv · May 21, 2026 · PreprintImmunology