Patrick L. Collins

A CRISPRi screen identifies SON and MAP4K1 as regulators of IL-22 and IL-17 expression in innate lymphoid cells, revealing new therapeutic targets for immune-mediated diseases.

This study shows aging worsens cardiac dysfunction during Streptococcus pneumoniae infection through inflammation and impaired immune responses, with potential therapeutic targets identified.

This study identifies Aiolos as a negative regulator of antigen-inexperienced, virtual memory CD8+ T cells, showing increased TVM cell numbers and function in its absence.

This study shows that adding I3C to an HIV vaccine increases the cytotoxic memory-like responses of NK cells in mice.

The paper identifies ERK5 as a potentiator of STAT1 activation and ISG expression, enhancing type III IFN-mediated antiviral responses in epithelial cells.

This study characterizes epigenetic aging in human classical monocytes, identifying age-associated DNA methylation changes and their links to gene expression and disease associations.