An acidic loop in the FHA domain of the yeast meiosis-specific kinase Mek1 interacts with a specific motif in a subset of Mek1 substrates
Qixuan Weng, Lihong Wan, Geburah C. Straker, Tom D Deegan, Bernard P. Duncker, Aaron M. Neiman, Ed Luk, Nancy M. Hollingsworth
This paper identifies a non-canonical interaction between the FHA domain of the yeast kinase Mek1 and RPXKR motifs in its substrates Ndt80 and Rrm3, validated through AlphaFold modeling and genetic analysis.
bioRxiv · May 24, 2024 · PreprintGenetics