Tom D Deegan

This study identifies ATRX deficiency as a driver of aberrant type I interferon signaling via cGAS-dependent transcriptional dysregulation in patients with cerebral white matter disease.

This study investigates how telomeres impede replication by showing G-rich DNA and shelterin subunit POT1 block lagging strand replication, with POT1 causing Okazaki fragment skipping and large single-stranded gaps.

This study shows that CMG helicase disassembly is essential in budding yeast and occurs via two pathways involving ubiquitylation and Rrm3/Pif1 helicases.

This study identifies TOM20, TOM70, TOM40, and associated subunits as critical for PINK1 activation in a reconstituted yeast system, providing insights for PINK1 activator development.

This paper identifies a non-canonical interaction between the FHA domain of the yeast kinase Mek1 and RPXKR motifs in its substrates Ndt80 and Rrm3, validated through AlphaFold modeling and genetic analysis.