Ed Luk

This paper shows that SEN1 has three distinct roles in yeast meiosis: enabling IME1 gene expression, preventing DNA:RNA hybrid accumulation, and facilitating double strand break repair and chromosome synapsis.

This paper identifies a non-canonical interaction between the FHA domain of the yeast kinase Mek1 and RPXKR motifs in its substrates Ndt80 and Rrm3, validated through AlphaFold modeling and genetic analysis.

The paper identifies that nucleic acid sequences, specifically polyadenine tracks, contribute to the targeting of H2A.Z by the SWR chromatin remodeler beyond canonical NDRs and acetylation sites.

The paper uses live-cell single particle imaging to show that RNA polymerase II and Kin28/Cdk7 kinase are required for H2A.Z eviction in yeast, linking it to transcription processes.