Cancer BiologybioRxivPreprint
Targeting the COP9 signalosome overcomes platinum resistance in ovarian cancer through two distinct genome stability mechanisms
Elena Lomonosova, Megan Loeb, Kevin Rodriguez…·Mary Margaret Mullen
The paper identifies COPS5 as a therapeutic target for overcoming platinum resistance in ovarian cancer by inhibiting nucleotide excision repair and interstrand crosslink repair.
DOI 10.1101/2025.08.04.668450