BiochemistrybioRxivPreprint
The expression of congenital Shoc2 variants induces AKT-dependent feedback activation of the ERK1/2 pathway
Patricia Wilson, Lina Abdelmoti, Tianyan Gao, Emilia Galperin
This study shows that Shoc2 variants associated with NSLH alter ERK1/2 phosphorylation levels depending on AKT pathway activation, revealing a feedback mechanism in EGFR signaling.
DOI 10.1101/2023.12.23.573219