Human Regnases are antiviral restriction factors targeting viral RNA
Linda Grabe, Sarah Hommel, Lucas Singer, Maddalena Zangari, Kerstin Regensburger, Asimenia Vlachou, Rayhane Nchioua, Konstantin M. J. Sparrer, Mateusz Wawro, Aneta Kasza, Daniel Sauter, Frank Kirchhoff, Dorota Kmieć
This study identifies Regnases as antiviral restriction factors in humans, showing they inhibit RNA viruses but not DNA viruses, with varying substrate selectivity among the four Regnases.
bioRxiv · Aug 24, 2026 · PreprintImmunology