Parkinson's disease-associated LRRK2 risk variant, G2385R, enhances Rab substrate phosphorylation and impairs neuronal integrity
An Phu Tran Nguyen, Roger Moser, Nicole Bryant, Lindsey A. Cunningham, Evan J. Worden, Darren J. Moore
This study evaluates how LRRK2 coding variants affect protein function and neurotoxicity, finding that G2385R increases Rab10 phosphorylation and impairs neuronal integrity.
Human Molecular Genetics · Jan 1, 2026Peer-reviewedNeuroscience