Author
Van Andel Institute
Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.
5 papers
Recent·Most cited
An Phu Tran Nguyen, Roger Moser, Nicole Bryant…·Darren J. Moore
This study evaluates how LRRK2 coding variants affect protein function and neurotoxicity, finding that G2385R increases Rab10 phosphorylation and impairs neuronal integrity.
Dylan J. Dues, Madalynn L. Erb, Alysa Kasen…·Darren J. Moore
This study shows that pathological α-synuclein can cause granulovacuolar degeneration independently of tau, using a mouse model of α-synucleinopathy.
Dylan J. Dues, Yue Ma, An Phu Tran Nguyen…·Darren J. Moore
This study shows that LRRK2 does not significantly affect the formation of α-synuclein inclusions in the forebrain of mice after PFF injection, but may influence microglial activation.
Dylan J. Dues, An Phu Tran Nguyen, Katelyn Becker…·Darren J. Moore
This study shows that α-synuclein fibrils injected into mouse forebrain cause regional pathology, early neuronal degeneration, and cognitive deficits resembling Lewy body diseases.
An Phu Tran Nguyen, Elpida Tsika, Kaela Kelly…·Darren J. Moore
This study develops a rat model of Parkinson's disease caused by the G2019S LRRK2 mutation and shows that kinase and GTPase activities are critical for neurodegeneration.