Evan J. Worden

This study identifies a feed-forward mechanism where UHRF1 reads and writes H3 mono-ubiquitination to maintain DNA methylation at CpG-sparse regions.

This study shows how bacterial effector RomA is regulated by host histone modifications, revealing a new layer of host-pathogen interaction through epigenetic crosstalk.

This study evaluates how LRRK2 coding variants affect protein function and neurotoxicity, finding that G2385R increases Rab10 phosphorylation and impairs neuronal integrity.

This study presents cryo-EM structures of active H/ACA snoRNPs, revealing inter-protomer interactions and how mutations affect pseudouridine formation and ribosome biogenesis.

This study reveals the molecular mechanism of DNMT3A-3L-mediated de novo DNA methylation through structural analysis of its chromatin interactions and regulatory dynamics.

This study identifies a hetero-trimeric complex formed by Setdb1 and two Atf7IP copies that blocks Setdb1 nuclear export by competing with CRM1.

This study reports Cryo-EM structures of DNMT3A2/3B3 bound to di-nucleosomes, revealing how linker length and H3K36 methylation influence DNA methylation.

The paper reports the cryo-EM structure of a COMPASS subcomplex bound to a ubiquitinated nucleosome, revealing how H2B ubiquitination stimulates H3K4 methylation.