Author

Nicole Bryant

Duke University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Assay:proteomics· 3 Research Focus:differential expression· 2 Organism:mouse· 2 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

Andrew B. WestiD· 2 shared Darren J. MooreiD· 2 shared Ravindra Boddu· 2 shared Allison ChangiD· 1 shared An Phu Tran Nguyen· 1 shared Arpine SokratianiD· 1 shared Ashley S. HarmsiD· 1 shared Aubrey M SchonhoffiD· 1 shared

Activity by Year

2020-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersNeuroscience

Andrew B. WestORCID

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3 papers

Recent·Most cited

Parkinson's disease-associated LRRK2 risk variant, G2385R, enhances Rab substrate phosphorylation and impairs neuronal integrity

An Phu Tran Nguyen, Roger Moser, Nicole Bryant, Lindsey A. Cunningham, Evan J. Worden, Darren J. Moore

This study evaluates how LRRK2 coding variants affect protein function and neurotoxicity, finding that G2385R increases Rab10 phosphorylation and impairs neuronal integrity.

Human Molecular Genetics · Jan 1, 2026Peer-reviewedNeuroscience

Single molecule array measures of LRRK2 kinase activity in serum link Parkinson's disease severity to peripheral inflammation

Yuan Yuan, Huizhong Li, Kashyap Sreeram, Tuyana B. Malankhanova, Ravindra Boddu, Samuel Strader, Allison Chang, Nicole Bryant, Talene A. Yacoubian, David G. Standaert, Madalynn L. Erb, Darren J. Moore, Laurie H. Sanders, Michael William Lutz, Dmitry Velmeshev, Andrew B. West

The paper measures LRRK2 kinase activity via pT73-Rab10 in serum, linking it to inflammation and Parkinson's disease severity.

Molecular Neurodegeneration · Jun 11, 2024Peer-reviewedNeuroscience

Pathologic α-Synuclein Species Activate LRRK2 in Pro-Inflammatory Monocyte and Macrophage Responses

Enquan Xu, Ravindra Boddu, Hisham Abdelmotilib, Kaela Kelly, Arpine Sokratian, Ashley S. Harms, Aubrey M Schonhoff, Nicole Bryant, Irene E. Harmsen, Michael G. Schlossmacher, Sidhanth Chandra, Valentina Krendelshchikova, Zhiyong Liu, Andrew B. West

The paper shows that α-synuclein fibrils activate LRRK2 kinase in monocyte-derived macrophages, linking LRRK2 mutations to pro-inflammatory responses in Parkinson's disease.

bioRxiv · May 4, 2020 · PreprintNeuroscience