Tumor cells upregulate CCL22 in a STING-dependent manner in response to paracrine factors released by STING-activated myeloid cells and type I interferons
Elmira M. Lomashvili, Jihyun Kim, Lingwei Kong, Pamela R. Cook
The paper shows that STING activation in myeloid cells leads to paracrine factors that upregulate CCL22 in cancer cells, and that type I interferons also induce CCL22 via a STING-dependent mechanism.
ImmunoHorizons · Sep 17, 2025Peer-reviewedCancer Biology