BET inhibition induces GDH1-dependent glutamine metabolic remodeling and vulnerability in liver cancer
Wen Mi, Jianwei You, Liucheng Li, Lingzhi Zhu, Xinyi Xia, Li Yang, Fei Li, Yi Xu, Junfeng Bi, Pingyu Liu, Fuming Li
This study shows BET inhibition in liver cancer reduces proliferation by inducing GDH1-dependent glutamine metabolic changes, suggesting a therapeutic strategy combining BET and OXPHOS inhibitors.
Life Metabolism · Apr 24, 2024Peer-reviewedCancer Biology