The paper reports a method using LIFT technology to obtain high-quality microbial single-cell genomes or transcriptomes from complex samples and demonstrates its application to study cell-fate commitment in sporulation.

Cell Genomics · Jan 22, 2026Peer-reviewedMicrobiology

SkeletAge: Transcriptomics-based Aging Clock Identifies 26 New Targets in Skeletal Muscle Aging

Muhammad Ali, Fei Li, Manpreet Singh Katari

The paper introduces SkeletAge, a bulk RNA-seq-based aging clock that identifies 26 novel genes in skeletal muscle aging and links them to aging phenotypes and drug targets.

bioRxiv · Jul 28, 2025 · PreprintBioinformatics

BET inhibition induces GDH1-dependent glutamine metabolic remodeling and vulnerability in liver cancer

Wen Mi, Jianwei You, Liucheng Li, Lingzhi Zhu, Xinyi Xia, Li Yang, Fei Li, Yi Xu, Junfeng Bi, Pingyu Liu, Fuming Li

This study shows BET inhibition in liver cancer reduces proliferation by inducing GDH1-dependent glutamine metabolic changes, suggesting a therapeutic strategy combining BET and OXPHOS inhibitors.

Life Metabolism · Apr 24, 2024Peer-reviewedCancer Biology

Rbm10 facilitates heterochromatin assembly via the Clr6 HDAC complex

Martina Weigt, Qingsong Gao, Hyoju Ban, Haijin He, Guido Mastrobuoni, Stefan Kempa, Wei Chen, Fei Li

This study identifies Rbm10 as a splicing factor that facilitates heterochromatin assembly through its interaction with the Clr6 HDAC complex in fission yeast.

Epigenetics & Chromatin · Jan 19, 2021Peer-reviewedMolecular Biology