Decoding Neoantigen-encoding Tumor-Specific Transcripts Unveils a Shared Target Reservoir for Immunotherapy in Hepatocellular Carcinoma
Peng Lin, Yifan Wen, Jingjing Zhao, Feifei Zhang, Yaoming Su, Hongwu Yu, Yu Hx, Qiaojuan Li, Chengye Liu, Zhixiang Hu, Yan Li, Zhuting Fang, Linhui Liang, Shenglin Huang
This paper identifies neoantigen-encoding tumor-specific transcripts (neoTSTs) in hepatocellular carcinoma, showing they are more abundant and immunogenic than mutation-derived neoantigens, and demonstrate therapeutic potential in preclinical models.
Journal for ImmunoTherapy of Cancer · Jul 1, 2026Peer-reviewedCancer Biology